Neuropathic pain causes and treatments

Neuropathic pain

Peripheral neuropathic pain has numerous possible causes. Besides a physical exam, which may include blood testing, diagnosis typically requires:

A thorough medical history. Your doctor will assess your medical history, including your symptoms, lifestyle, exposure to chemicals, drinking habits and a family history of nerve system (neurological) problems.
Neurological examination. Your doctor could assess your tendon reflexes, your muscle strength and tone, your ability to sense particular sensations, and your posture and coordination. By lowering the amount of chemical molecules produced in the brain that carry pain signals, it lessens pain. Pregabalin 150 mg or Pregalin 50 mg drug helps to regenerate damaged nerve cells and protects nerve fibres. It must be consumed precisely as directed by the doctor, in the amounts, and for the allotted amounts of time.

Neuropathic discomfort Treatment

The aim of treatment are to address the disease producing neuropathy and alleviate symptoms. Whether your lab results suggest that there is no underlying problem, your doctor may propose a period of observation to see if your neuropathy improves.


In addition to drugs used to treat peripheral neuropathy-related disorders, the following medications are used to alleviate peripheral neuropathy symptoms:

Pain remedies: Mild symptoms may be alleviated with over-the-counter pain medicines, such as nonsteroidal anti-inflammatory agents. For more severe symptoms, your physician may prescribe pain relievers.

Opioid-containing medications, such as tramadol (Conzip, Ultram, and others) and oxycodone (Oxycontin, Roxicodone, and others), may cause dependency and addiction; thus, these medicines are typically not administered until all other treatment options have failed.

Anti-seizure medicines:  Medications designed to treat epilepsy, such as gabapentin (Gralise, Neurontin, Horizant) and pregabalin (Lyrica), may alleviate nerve discomfort. There might be tiredness and dizziness as side effects.

Topical therapies: Capsaicin cream, which includes a compound found in hot peppers, may bring about small improvements in peripheral neuropathy symptoms. You may have skin irritation and burning where you apply the lotion, although this often subsides with time. However, some individuals cannot endure it.

Lidocaine patches are another topical pain-relieving therapy that may be applied to the skin. The patch may cause sleepiness, dizziness, and numbness at the application location.

Antidepressants: Certain tricyclic antidepressants, such as amitriptyline, doxepin (Silenor, Zonalin), and nortriptyline (Pamelor), have been discovered to alleviate pain by interfering with chemical processes in the brain and spinal cord that generate pain.

Additionally, the serotonin and norepinephrine reuptake inhibitor duloxetine (Cymbalta, Drizalda Sprinkle) and the extended-release antidepressants venlafaxine (Effexor XR) and desvenlafaxine (Pristiq) may alleviate the discomfort of diabetic peripheral neuropathy.

Antidepressants may cause dry mouth, nausea, sleepiness, vertigo, changes in appetite, weight gain, and constipation as unwanted side effects.

Pain management for neuropathic pain

Diverse pharmacotherapies and medical procedures may help alleviate the symptoms of peripheral neuropathy.

Transcutaneous electrical nerve stimulation (TENS) (TENS): Electrodes put on the skin produce a mild, variable-frequency electric current. TENS should be administered everyday for 30 minutes for about one month.
Plasma exchange and immune globulin administered intravenously. These methods, which assist reduce immune system activity, may be advantageous for individuals with certain inflammatory diseases.

Plasma exchange entails extracting your blood, eliminating antibodies and other proteins, and then reinfusing the blood. Immunoglobulin treatment involves the administration of large concentrations of antibodies-forming proteins (immunoglobulins).

Physical rehabilitation: If you suffer from muscular weakness, physical treatment may enhance your mobility: Additionally, you may need hand or foot braces, a cane, a walker, or a wheelchair.
Surgery: Neuropathies induced by pressure on nerves, such as pressure from tumours, may need surgical intervention to relieve the pressure.

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